Illumina's inaugural in-person Genomics Forum 2022 in San Diego, USA, from 28 September - 1 October 2022 sent a clear message that the genomic health revolution is here. This trailblazing event brought together global leaders, scientific researchers, medics, policy makers, the data and technology sector and beyond to advance and push the boundaries of what is possible in the genomic era. Its collaborative and innovative approach, combined with its positive call to action, delivered an inspiring message of hope for the broad and effective use of genomic technology to deliver precision and preventative healthcare and disease surveillance to prevent the next pandemic.